HPLC Column


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The C18 column with the World’s best suppressed silanol activity

This is the column recommended as the first choice for you to start a new method development as well as a simultaneous analysis of multicomponents ranging from polar to hydrophobic compounds.

Analysis of basic compounds even under a neutral condition

Have you ever experienced a peak profile problem with a basic compound?
Have you ever been aware of that your sample may also be a basic compound?

With MGII, the strongest silanol activity suppression achieved by the most advanced technology (Ultimate Polymer Coating), ensuring good peak profile even under neutral condition, the most severe for the peak profile of basic compounds.

What's more, this column due to the relatively higher surface polarity of the packing material can be used for a wide range of samples, from polar down to hydrophobic compounds.
This is the ultimate HPLC column from Osaka Soda to start with.
This is the first choice. CAPCELL PAK C18 MGII is what we recommend to you.


From polar to hydrophobic compounds

As a C18 column, MGII positions at moderate hydrophobicity and high polarity. It was developed to cover a wide range of applications of acidic-neutral-basic compounds, from low to high polar compounds. Easiest to see that the residual silanol activity was definitely controlled with MGII by showing the chromatogram of a basic compound, Amitriptyline under neutral mobile phase conditions in the Validation Sheet.

Hydrophobicity and surface polarity parameters of Osaka Soda columns

With sharp peaks even under neutral condition, MGII finds more possibility for your analysis

Why do we insist on the analysis of basic compounds in a neutral condition?
Because drugs and physiologically active substances often have basic sites, many of our customers who employ chromatography, including pharmaceutical manufacturers, asked for columns providing excellent peak profiles for basic compounds.

Since MGII has succeeded in providing sharp peaks even under the neutral condition, there is no need to set up specific conditions for analysis even for basic compounds. MGII simply achieves your goals your way.

Why the neutral condition? Basic components?


No.1 in the triangle properties (number of theory plate, tailing factor, pressure) and No. 1 in user friendliness

When you choose a column, what do you care about most?
Isn't it separation, good peak profile and low pressure?

These factors have been compared. MGII has a higher number of theory plate, with a tailing factor most closed to 1 and lower pressure, presenting an excellent balance of the three factors.
It is easy to handle even when you are using the HPLC for the first time.

Fig. 1Analysis with volatile salts


MGII S3 enables efficient high-throughput analysis with
a high flow rate!

The downsizing from 5µm to 3µm led to a larger number of theory plate and the shortening of column length reduce analysis time. Moreover, as MGII S3 has been designed to realize the maximum number of theory plate with double the normal flow rate, you are able to efficiently realize a still higher throughput in your analysis!

Fig. 23-µm particle developed for analysis of high throughput


Applicable in a wider range with excellent resistance to acid and alkaline

Thanks to the Ultimate Polymer Coating over the base silica material, you are able to use the column over a wide range of pH, from 2 to 10, while realizing high –performance separation.

Column with GLP/GMP support

In addition to Column Report showing the test chromatogram, the CAPCELL PAK C18 MGII Column (particle diameter: 3 µm, 5 µm) is provided with an inspection certificate as a GLP/GMP-supported packing material.

With MGII, 3 different lots are available for one shipment to facilitate you to set up analysis conditions for the first time. Please place an order for a set of 3 different lots. We provide the support to assure you a reliable setup of conditions.

Physical properties

surface area
C% Density
Range of
acceptable pH
Octadecyl group 3 10 300 16 2.6 2~10 L1
Octadecyl group 5 10 300 16 2.6 2~10 L1
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