HPLC Column

Chiral CD-Ph

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A Chiral column for chiral separation with silica-based phenylcarbamated β-cyclodextrin as the chiral selector.

For those looking to achieve chiral separation of racemic mixture with a structure comprising benzene rings, we provide sufficient retention with phenylcarbamate and excellent selectivity with β-cyclodextrin.

Are you worried about finding a Chiral column that hits your enantiomers target?
The Chiral CD-Ph column presents "Phenyl carbamated β-cyclodextrin" as a functional group. The outstanding retention made possible with phenyl carbamate and the excellent selectivity made possible with β-cyclodextrin raise the hit rate of your samples.

If your samples contain a benzene ring, and if they are basic and/or neutral compounds, the Chiral CD-Ph may be just what need for chiral separation.


Certainly retained and separated with Phenyl carbamated β-cyclodextrin

Chiral CD-Ph is packing material for chiral separation created from a precisely classified high-purity spherical silica with phenyl carbamate beta-cyclodextrin chemically bonded as a chiral selector.

The balance between the hydrophobicity and polarity of phenylcarbamate assures sample retention, and the central cavity of β-cyclodextrin presents excellent chiral recognition with inclusion.


Excellent chiral selectivity

Chiral CD-Ph excels at the chiral separation of basic and neutral compounds.

Applications of chiral separation

Separation Factors (α) on Columns (Osaka Soda) for Optical Separation
Compound Column* α Temp Eluent
Neutral Compound
Bendroflumethiazide CD 2.40 25°C 0.5mol/L
Benzoin methyl ether CD 1.12 25°C i-C3H7OH/n-C6H14
1-(4-Bromophenoxy)-1-ethoxyetane CD 1.17 25°C H2O/CH3OH=3/7
2-Bromo-1-phenylpropane CD 1.03 25°C H2O/CH3OH=4/6
2-Bromo-N-phenylpropionamide CD 1.12 25°C C2H5OH/n-C6H14=1/9
Carvone CD 1.14 25°C H2O/CH3OH=3/7
2,4-Dichloro-α-methylbenzyl alcohol CD 1.05 25°C H2O/CH3OH=1/1
2,2-Dimethyl-1-phenyl-1-propane CD 1.03 25°C H2O/CH3CN=6/4
1,2-Epoxy-3-phenoxypropane CD 1.11 25°C C2H5OH/n-C6H14=4/6
(2,3-Epoxypropyl)Benzene CD 1.22 25°C H2O/CH3OH=3/7
Flavanone CD 1.56 25°C H2O/CH3OH=1/9
Hexobarbital CD 1.32 25°C C2H5OH/n-C6H14=4/6
Mandelonitrile CD 1.05 25°C C2H5OH/n-C6H14=2/8
2-Methoxy-2-phenylethanol CD 1.17 25°C H2O/C2H5OH=6/4
1-Phenyl-1,2-ethanediol CD 1.11 5°C H2O/CH3OH=6/4
1-Phenylethanol CD 1.10 25°C H2O/CH3CN=6/4
1-Phenyl-1-propanol CD 1.19 15°C H2O/CH3CN=8/2
Triadimefon CD 1.03 25°C i-C3H7OH/CH3OH/n-C6H14
Compound Column* α Temp Eluent
Basic compound
Alprenolol CD 1.30 25°C 0.5mol/L
Atenolol CD 1.21 25°C 0.5mol/L
Atropine CD 1.10 25°C 0.5mol/L
4-Chloroamphetamine CD 1.86 25°C 0.5mol/L
2-(Ethylamino)propiophenone CD 1.44 25°C 0.5mol/L
Homatropine CD 1.05 25°C 0.5mol/L
Isoprotenol CD 3.01 25°C 0.5mol/L
α-(Methylaminometyl)benzyl alcohol CD 1.49 60°C 0.5mol/L
2-(methylamino)propiophenone CD 2.29 25°C 0.5mol/L
Metanephrine CD 1.08 25°C 20mmol/L
Metoprolol CD 1.15 25°C 0.5mol/L
1-(1-Naphthyl)ethylamine CD 1.26 25°C 0.5mol/L
Nicardipine CD 1.13 25°C 0.5mol/L
Norphenylephrine CD 2.71 25°C 50mmol/L
Norepinephrine CD 1.36 25°C 50mmol/L
Oxyphencyclimine CD 1.06 15°C 0.5mol/L
Perhydroindol CD 1.08 25°C 20mmol/L
1-Phenylethylamine CD 1.62 25°C 0.5mol/L
Phenylephrine CD 1.89 25°C 0.5mol/L
Pindolol CD 1.21 25°C 0.5mol/L
Propranolol CD 1.66 25°C 0.5mol/L
Synepherine CD 1.84 25°C 0.5mol/L
Tetrahydropapaveroline CD 1.96 25°C 50mmol/L
Thioridazine CD 1.10 25°C 20mmol/L

*:CD:Chiral CD-Ph
The list of chiral compounds non- separable with Osaka Soda columns Acephate, Camphorquinone, Catechin, 3,3,3-Trifluoro-2-methoxy-2-phenylpropanenitorile, Pantoyl lactone, 1-Phenoxy-2-propanol, 2-Phenyl-2-butanol, 2,2,2-Trifluoro-1-(9-anthryl)ethanol, Tetrahydro-3-furoic acid, N-Acetylprocainamide, 2-Amino-1-(4-hydroxyphenyl)-1-propanol, 1-Acetoxy-8-hydroxy-1,4,4a,9a-tetrahydroanthraquione, Anabasine, Carbinoxamine, 5-Ethyl-5,6-dihydro-3,8-dinitro-6-phenyl-6-phenanthridinol, Laudanosoline, Arginine, Histidine, Lysine


Method study according to the customary procedures.

The Chiral CD-Ph column is capable of using mobile phase in normal as well reversed-phase mode. First select the separation mode according to sample solubility.
After this, examine conditions according to the customary procedures.

Flow chart

General Characteristics
[Temperature]At a lower temperature, the separation performance is higher, the retention time is longer, and the pressure is higher.[Flow rate] At a lower flow rate, the separation performance is higher but the retention time is longer.[Mobile phase]- Aqueous (reversed phase):Increasing the water content improves the separation performance but increases the retention time, lowers the sensitivity, and raises the pressure.- Hexane (normal phase):Increasing the hexane content improves the separation performance but increases the retention time, lowers the sensitivity, and raises the pressure.
Notes on use
When using RU-1, do not use water or solvent that contains water; doing so will destroy the column. To prevent the moisture, note the following: Use a new solvent for liquid chromatograph as the solvent Before use, thoroughly rinse the system tubing with this mobile phase Minimize the amount of amine because an aqueous solution containing amine may facilitate a rise in pressure
Methanol cannot be mixed into hexane over 4% but will produce sharper peaks than ethanol.
When an acetic acid solution is used, the waste liquid is slightly colored but the column performance is not affected. Dispose of the waste liquid as heavy metal waste.
The derivatization method is as follows


High loadability

As Chiral CD-Ph is capable of processing a high load volume per analysis, efficient preparation is realized.
Moreover, thanks to the use of precisely graded high-purity silica gel, low pressure is also a noteworthy feature. Column sizes suitable for preparative separation are also available. Chiral CD-Ph provides you extended work from analytical to preparative separation with confidence.

Data 1 :High sample load


Excellent durability

Chiral CD-Ph's excellent durability provides solid support for long-term R&D projects such as the development of new pharmaceutical products or raw materials.

Data 2 :Excellent durability


Physical properties

Type Particle
surface area
Range of
acceptable pH
CD-Ph 5 8 350 3.5〜6.5
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