The introduction of UHPLC presents a slightly high hurdle…
But I want to realize the analysis of high separation with the HPLC at hand.
I want to extract the maximum performance out of the UHPLC also in separation.
For those experiencing difficulties in the separation of isomers or fluorine compounds in both UPLC and UHPLC with C₁₈ columns, CAPCELL CORE PFP provides new possibilities.

CAPCELL CORE is a polymer-coating type core-shell column. It comprises a core-shell type packing material with a 2.7-µm superficially porous particle presenting a layer of porous silica of 0.5 µm around a 1.7- µm solid core. It can reach high separation naturally, not only in UHPLC but also in HPLC.

Features

PFP advances the separation of structural isomers

Compared with C₁₈ columns, PFP presents specific resolution in the analysis of position isomers. Furthermore, due to its structural properties as a core-shell type packing material, CAPCELL CORE PFP presents separation performance equivalent to that of the totally porous Sub2-µm column while keeping the the column pressure not too high. CAPCELL CORE PFP is the most suitable column not only for the analysis in UHPLC but also for improving resolution and reducing analysis time in HPLC.

Specific retention of fluorine compounds

CAPCELL CORE PFP also exercises its separation performance in the analysis of fluorine compounds frequently used in pharmaceuticals.

Physical properties

Functional group	Particle diameter (µm)	Pore diameter (nm)	Specific surface area (m2/g)	C%	Range of acceptable pH	USP
Pentafluorophenyl group	2.7	9	150	5	2～8	L43