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HPLC Column

Capcell Pak ADME-HR Type

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The only-one column changing the separation pattern of the reversed phase with a completely novel functional group.

Bring you separation patterns unavailable with all popular C18 columns in the analysis of highly polar compounds such as metabolites.

If these polar compounds can be retained, separation of other components may become easy… Have you ever had problems in analyzing components difficult to retain in C18 columns? I don't really want to change the separation mode. I would rather do the analysis in the reverse phase mode… Our focus is on the development of a column just right for your requirements.

Capcell Pak ADME-HR introduces the adamantyl group, with a completely different structure to the conventional octadecyl group, as the functional group. The implementation rate is tightly controlled at an optimized density in order to make the performance of ADME group in maximum.
This provides a balance between a hitherto unavailable hydrophobicity and surface polarity of the particles.

ADME brings you separation patterns unavailable with conventional C18 columns.

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Features

Nonconventional separation patterns derived by the high surface polarity

The Capcell Pak ADME-HR maintains a balance between hydrophobicity with surface polarity which is completely different to conventional particles, and provides previously unavailable separation patterns.

In particular, in comparison to conventional C18 columns, increased retention to highly polar compounds has been demonstrated.

Nonconventional separation patterns derived by the high surface polarity

Highly Stable under 100 % Water Mobile Phases

As shown on the right, the efficiency is very stable even after 600 injections under acidic mobile phase.

HPLC conditions

Results after 600 consecutive injections, Variation of Efficiency of Thymine

Analysis of Nucleic-Acid Bases and Nucleosides via Gradeient Elution

As shown below, the unique selectivity provided from CAPCELL PAK ADME-HR shows complete separation for all analytes, but with stronger retention of polar analytes.

Analysis of Nucleic-Acid Bases and Nucleosides via Gradeient Elution

CAPCELL PAK ADME-HR S5

HPLC Conditions

Retention Behavior of Biogenic Amines under 100 % Water Mobile Phase

As shown below, CAPCELL PAK ADME-HR offers stronger retention of polar analytes, resulting in delivering complete separation for all analytes.

Analysis of Nucleic-Acid Bases and Nucleosides via Gradeient Elution

CAPCELL PAK ADME-HR S3,CAPCELL PAK ADME-HR S5

HPLC Conditions

Physical properties

Functional
group
Particle
size
(μm)
Pore
size
(nm)
Specific
surface area
(m2/g)
Density
(µmol/m2)
C% Acceptable pH
USP
Adamantyl group 2 10 310 2.7 12 2~9
Adamantyl group 3 10 310 2.7 12 2~9
Adamantyl group 5 10 310 2.7 12 2~9
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