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- Capcell Pak ADME-HR Type
The only-one column utilizing ADAMANTINE, a completely new functional group that is changing the separation pattern of the reversed phase chromatogram.
Bring you separation patterns unavailable with the popular regular C18 columns in the analysis of highly polar compounds such as metabolites.
If these polar compounds can be retained, separation of other components may become easy… Have you ever had problems in analyzing components difficult to retain in C18 columns? It would be difficult to change the separation mode, it is rather better to keep the analysis in the reverse phase mode… Our focus is on the development of a column just right for your requirements.
Capcell Pak ADME-HR introduces the Adamantyl group, with a completely different structure to the conventional octadecyl group, as the functional group. The implementation rate is tightly controlled at an optimized density in order to make the
performance of ADME group in maximum.
This provides a balance between a hitherto unavailable hydrophobicity and surface polarity of the particles.
ADME brings you separation patterns unavailable with conventional C18 columns. The diamond-like strength of Adamanitine provide diamond-sharp peaks.
Features
Non-conventional separation patterns derived by the high surface polarity
The Capcell Pak ADME-HR maintains a balance between hydrophobicity with surface polarity which is completely different to conventional particles and provides previously unavailable separation patterns.
In particular, in comparison to conventional C18 columns, increased retention to highly polar compounds have been demonstrated.
Highly Stable under 100 % Aqueous Mobile Phases
As shown on the right, the efficiency is very stable even after 600 injections under acidic mobile phase.
Analysis of Nucleic-Acid Bases and Nucleosides via Gradient Elution
As shown below, the unique selectivity provided from CAPCELL PAK ADME-HR shows complete separation for all analytes, but with stronger retention of polar analytes.
Retention Behavior of Biogenic Amines under 100 % Water Based Mobile Phase
As shown below, CAPCELL PAK ADME-HR offers stronger retention of polar analytes, resulting in delivering complete separation for all analytes.
Physical properties
| Functional group |
Particle size (μm) |
Pore size (nm) |
Specific surface area (m2/g) |
Density (µmol/m2) |
C% | Acceptable pH USP |
|---|---|---|---|---|---|---|
| Adamantyl group | 2 | 10 | 310 | 2.7 | 12 | 2～9 |
| Adamantyl group | 3 | 10 | 310 | 2.7 | 12 | 2～9 |
| Adamantyl group | 5 | 10 | 310 | 2.7 | 12 | 2～9 |
