HPLC Instruments

Aerosol-based detector NANOSPACE NQAD

Capture the ingredients overlooked until now in high-sensitive detection - the 3rd Detector -

It is a "universal" detector that enables high sensitivity detection by employing the specific Water Condensation Particle Counter (WCPC) technology.

Ultimate "universal", yet in high sensitivity!

Are you using a detector with high selectivity?

Selectivity is definitely important factor to enable the determination only for the target substance with a detector of high selectivity.

In other hand, nobody can forget that sample introduced into the HPLC system always includes components with a wide range of chemistries.


Aerosol-based detector NQAD

With the sample, have you been worried about if your target component had been certainly detected, or the important component might have been missed because of the high selectivity?

While now when highly selective detection has become possible for specific target, again, here is our new solution for those who wants to

"capture the whole picture of the sample"
"confirm certain separation"
"make further optimization to the analysis conditions"

NQAD is ultimately oriented to high sensitive detection of a wide range of substances including compounds with no chromophore, poor ionizability, and no electrochemical reactivity as well as unknown nature from semi-volatile to volatile. The "detects all" nature of the detector opens a new category of LC applications.

NANOSPACE NQAD, delivers experience with universal and high sensitive detection.


Universal detection

NQAD Provides high sensitive detection to compounds with no chromophore and poor ionizability.

Analysis of tranexamic acid combined in skin lotion

Who needs NQAD?

NQAD will advance the deteciton in many fields


  • Monosacharide
  • Disaccharide, Oligosaccharide
  • Polysaccharide
  • Sugar Alcohol etc.


  • Impurity Test
  • Antibiotics
  • Antibody
  • Resolvent etc.


  • Phospholipid
  • Fact Acid
  • Steroid
  • Triglyceride etc.


  • Cation Surfactant
  • Anion Surfactant
  • Nonionic Surfactant
  • Amphoteric Surfactant etc.


  • Polymer
  • Additives etc.

Amino Acid, Protein

  • Amino Acid
  • Peptide
  • Protein
  • Glycoprotein etc.


  • Counter Ion
  • Anion
  • Cation etc.

Sub nanogram (ng) sensitivity possible with the NQAD

Based on the unique technology WCPC technology, NQAD enables universal detection in high sensitivity.
Shown as an application of NQAD nanogram-order sensitivity was reached in the analysis of amino acid.

Analysis of amino acid

What is WCPC?

The Water-based Condensation Particle Counter (WCPC) technology condenses supersaturated water vapor onto the aerosol particles of analytes to form large droplets with increased density of the scattered light, which are counted as number of pulse signal when passing through the laser beam of an optical detector. Therefore, compared with that to count the density of scattered light, WCPC technology achieves improved sensitivity and wider dynamic range.

Wide linear range, generally from nanogram to microgram

In a conventional aerosol-based detectors, separated calibration curve is needed to match low-concentration range and high-concentration range respectively. Whereas, NQAD enables the detection with a single calibration because of the wide dynamic range feature.

Wide linear range, generally from nanogram to microgram


Product No. 5600
Power AC 100-240 V, 50/60 Hz, 157 W
Dimension(Unit) 180(W)×320(H)×430(D) mm
Weight(Unit) 10.8 kg
Software OpenLAB EZChrom
Principle Pulse Counting of scattered light of Water-Condensed Particle
Mobile phase flow rate 0.1 - 2.2 mL/min
Evaporator temperature 10 – 100 °C, programmable
Gas requirements Clean, dry air or nitrogen
MAX 4.7 L/min, 276 kPa (40 psi )
Nebulizer temperature 15 – 40 °C
Condensation liquid Distilled water
Wetted materials PFA, PTFE, ETFE, FEP, SUS316, PEEK, Ruby, FFKM
User interface 5" color touch screen display
Analog output 0 – 1.00 V
Data acquisition rate MAX 100 Hz
Connection Ethernet,USB
Page top